研究方向

1．BRAF、RAS等基因突變驅(qū)動(dòng)甲狀腺腫瘤惡變的新型分子機(jī)制；

2．碘難治性甲狀腺癌發(fā)生的分子機(jī)制及逆轉(zhuǎn)研究；

3．小分子化合物抑制甲狀腺癌生長(zhǎng)、轉(zhuǎn)移、失分化的藥理學(xué)研究；

4．腫瘤微環(huán)境與甲狀腺癌發(fā)生發(fā)展關(guān)系的研究；

5．其他臨床甲狀腺病變的病因、診斷及干預(yù)手段的研究；

6．核技術(shù)于碘難治性甲狀腺癌診治中的應(yīng)用研究。

獎(jiǎng)項(xiàng)、成果、課題等

國(guó)家自然科學(xué)基金項(xiàng)目5項(xiàng)

1. 張莉，國(guó)家自然科學(xué)青年基金，（81402214）轉(zhuǎn)錄因子MEF2A介導(dǎo)BRAF突變型甲狀腺乳頭狀癌發(fā)生發(fā)展的新機(jī)制，2015.1-2017.12 

2. 程獻(xiàn)，國(guó)家自然科學(xué)青年基金（81602352),表觀遺傳調(diào)節(jié)子MKL1介導(dǎo)轉(zhuǎn)錄復(fù)合物組裝促甲狀腺癌侵襲轉(zhuǎn)移的新機(jī)制，2017.1-2019.12 

3. 高巖巖，國(guó)家自然科學(xué)青年基金（81602353）,甲狀腺癌BRAF V600E在DRP1介導(dǎo)的線粒體穩(wěn)態(tài)中的調(diào)控新機(jī)制研究，2017.1-2019.12 

4. 張莉，國(guó)家自然科學(xué)基金面上項(xiàng)目（81972503), 腫瘤炎性微環(huán)境BRAF-組胺/組胺受體正反饋環(huán)路促進(jìn)甲狀腺乳頭狀癌失分化的新機(jī)制, 2020.1-2023.12 

5. 徐石宸, 國(guó)家自然科學(xué)青年基金(82103656),BRAF突變驅(qū)動(dòng)硫化氫-胱硫醚γ裂解酶體系失調(diào)促進(jìn)甲狀腺癌細(xì)胞淋巴結(jié)轉(zhuǎn)移的機(jī)制研究, 2022.1.1-2024.12

江蘇省自然科學(xué)基金1項(xiàng)

高巖巖, 江蘇省自然科學(xué)基金面上項(xiàng)目(BK20171145), 線粒體定位BRAF V600E調(diào)控線粒體凋亡抵抗甲狀腺癌放射性碘治療敏感性的研究, 2017.7-2020.6

江蘇省衛(wèi)健委項(xiàng)目 4項(xiàng)

1. 張莉 國(guó)家衛(wèi)生部科研基金（W201304），姜黃素對(duì)甲狀腺癌放射性碘-131治療的增敏研究，2014.1.1-2016.12.31

2. 張莉，省衛(wèi)計(jì)委面上項(xiàng)目（H2017032），基于炎癥因子早期預(yù)測(cè)甲狀腺癌分子靶向藥物療效的研究，2018.1-2019.12

3. 程獻(xiàn)，省健計(jì)委面上項(xiàng)目（M2021060），靶向BRG1/TERT復(fù)合物酶活促碘耐受甲狀腺癌放射敏感性的研究，2022.1-2024.12

4. 俞惠新，江蘇省衛(wèi)生廳科技項(xiàng)目（H2010027），放療增敏劑在抗碘-131甲狀腺癌治療中的應(yīng)用，2010.10～2013.9

無錫市科技局項(xiàng)目2項(xiàng)

1. 張莉, 無錫市科技局項(xiàng)目(Y20212051), 維生素C增強(qiáng)甲狀腺癌放射性碘-131治療敏感性的應(yīng)用研究；2021.7-2024.6

2. 程獻(xiàn), 無錫市科技局項(xiàng)目(Y20212052), BRG1介導(dǎo)TRET新酶活促甲狀腺癌碘抵抗的表觀調(diào)控機(jī)制研究, 2021.7-2024.6

無錫市衛(wèi)健委項(xiàng)目3項(xiàng)

1. 徐石宸，無錫市衛(wèi)健委科研項(xiàng)目（Q202103），硫化氫供體藥物靶向基質(zhì)金屬蛋白酶抑制甲狀腺癌轉(zhuǎn)移的實(shí)驗(yàn)研究，2022.1-2023.12

2. 徐石宸,無錫市衛(wèi)計(jì)委科研項(xiàng)目（Q201836），ZNF148多態(tài)性檢測(cè)用于甲狀腺結(jié)節(jié)良惡性鑒別的研究，2019.1-2020.12

3. 程獻(xiàn)，無錫市衛(wèi)計(jì)委青年項(xiàng)目（Q201608）MEF2A評(píng)估甲狀腺癌復(fù)發(fā)轉(zhuǎn)移風(fēng)險(xiǎn)的研究，2017.1～2018.12

代表性論文

近5年發(fā)表的甲狀腺疾病研究相關(guān)的代表性論文：

1)Cheng, X. et al. Risk-stratified Distant Metastatic Thyroid Cancer with Clinicopathological Factors and BRAF / TERT Promoter Mutations. Experimental and Clinical Endocrinology & Diabetes, 

doi:10.1055/a-2177-1051 (2023).

全文鏈接：/upload/autofile/20240307/202403077211.jpg  

2)Zhang, L. et al. Curcumin induces mitophagy by promoting mitochondrial succinate dehydrogenase activity and sensitizes human papillary thyroid carcinoma BCPAP cells to radioiodine treatment. 

Toxicology in Vitro 93, doi:10.1016/j.tiv.2023.105669 (2023).

全文鏈接：/upload/autofile/20240307/202403076583.jpg

3)Xu, S. et al. Inactivated SARS-CoV-2 vaccination does not disturb the clinical course of Graves' disease: An observational cohort study. Vaccine 41, 5648-5654, doi:10.1016/j.vaccine.

2023.07.053 (2023).

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4)Xu, S., Cai, G., Zhu, Y. et al. A Combination of BRAF and EZH1/SPOP/ZNF148 Three-Gene Mutational Classifier Improves Benign Call Rate in Indeterminate Thyroid Nodules. Endocr Pathol 34, 

323–332 (2023).

全文鏈接：/upload/autofile/20240307/202403072552.jpg  

5)Zhang, L. et al. Inflammatory tumor microenvironment of thyroid cancer promotes cellular dedifferentiation and silencing of iodide-handling genes expression. Pathology Research and Practice 

246, doi:10.1016/j.prp.2023.154495 (2023).

全文鏈接：/upload/autofile/20240307/202403072336.jpg

6)Wang, Y. et al. Diallyl trisulfide inhibits the metastasis of anaplastic thyroid carcinoma cells by targeting TGF-?-Smad3-integrin?2?1 signaling pathway. Process Biochemistry 124, 71-80, 

doi:10.1016/j.procbio.2022.11.009 (2023).

全文鏈接：/upload/autofile/20240307/202403071493.jpg

7)X. Cheng, S. Xu, Y. Zhu, et al., Markedly elevated serum preoperative thyroglobulin predicts radioiodine-refractory thyroid cancer, Eur. J. Clin. Invest. 2022, 52, e13721.

8)L. Wu, S. Xu, X. Cheng, et al., Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy-lysosome mediated OCT4A degradation, Phytotherapy Research. 

2022, 36, 938-950. 

全文鏈接：/upload/autofile/20240307/202403074663.jpg

9)L. Zhang, S. Xu, X. Cheng, et al., Curcumin induces autophagic cell death in human thyroid cancer cells, Toxicol. In Vitro 2022, 78, 105254.

全文鏈接：/upload/autofile/20240307/202403075104.jpg

10)S. Xu, X. Cheng, J. Wu, et al., Capsaicin restores sodium iodine symporter-mediated radioiodine uptake through bypassing canonical TSH-TSHR pathway in anaplastic thyroid carcinoma cells, 

Journal of Molecular Cell Biology. 2022, 13, 791-807.

全文鏈接：/upload/autofile/20240307/202403075733.jpg

11)L. Zhang, S. Xu, X. Cheng, et al., Curcumin enhances the membrane trafficking of the sodium iodide symporter and augments radioiodine uptake in dedifferentiated thyroid cancer cells via 

suppression of the PI3K-AKT signaling pathway, Food Function 2021, 12, 8260-8273.

全文鏈接：/upload/autofile/20240307/202403077853.jpg

12)L. Zhang, S. Xu, X. Cheng, et al., Diallyl trisulphide, a H2S donor, compromises the stem cell phenotype and restores thyroid-specific gene expression in anaplastic thyroid carcinoma cells 

by targeting AKT-SOX2 axis, Phytotherapy Research. 2021, 35, 3428-3443. 

全文鏈接：/upload/autofile/20240307/202403072241.jpg

13)X. Wang, S. Xu, L. Zhang, et al., Vitamin C induces ferroptosis in anaplastic thyroid cancer cells by ferritinophagy activation, Biochem. Biophys. Res. Commun. 2021, 551, 46-53.

全文鏈接：/upload/autofile/20240307/202403073154.jpg

14)S. Xu, X. Cheng, L. Wu, et al., Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload, Cellular 

Signaling. 2020, 75, 109733.

全文鏈接：/upload/autofile/20240307/202403076794.jpg

15)Xu S, Pan J, Cheng X, Zheng J, Wang X, Guan H, et al. Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC-1 cells through a positive feedback loop 

between H2S and cystathionine-gamma-lyase. Phytotherapy Research. 2020.

全文鏈接：/upload/autofile/20240307/202403073222.jpg

16)Zheng J, Cheng X, Xu S, Zhang L, Pan J, Yu H, et al. Diallyl trisulfide induces G2/M cell-cycle arrest and apoptosis in anaplastic thyroid carcinoma 8505C cells. Food Function. 2019;10(11):

7253-61.

全文鏈接：/upload/autofile/20240307/202403074175.jpg

17)Cheng X, Xu S, Pan J, Zheng J, Wang X, Yu H, et al. MKL1 overexpression predicts poor prognosis in patients with papillary thyroid cancer and promotes nodal metastasis. Journal of Cell 

Science. 2019;132(16).

全文鏈接：/upload/autofile/20240307/202403077061.jpg

18)Gao Y, Yang F, Yang X, Zhang L, Yu H, Cheng X, Xu S, Pan J, Wang K, Li P. Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer. The FEBS Journal.

2019;286: 1420-36.

全文鏈接：/upload/autofile/20240307/202403077188.jpg

19)Cheng X.#, Yao X.#, Xu S., Pan J., Yu H., Bao J., Guan H., Lu R., Zhang L.*. Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NF-kappaB 

signaling pathway. Biomedicine & pharmacotherapy. 2018; 103, 490-498.

全文鏈接：/upload/autofile/20240307/202403075913.jpg

20)Zhang L., Cheng X., Xu S., Bao J., and Yu H. Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells via disruption of 

intracellular calcium homeostasis. Medicine (Baltimore). 2018; 97, e11095.

全文鏈接：/upload/autofile/20240307/202403076040.jpg

21)Xu S., Zhang L., Cheng X., Yu H., Bao J., and Lu R. Capsaicin inhibits the metastasis of human papillary thyroid carcinoma BCPAP cells through the modulation of the TRPV1 channel. Food & 

Function. 2018; 9, 344-354. 

全文鏈接：/upload/autofile/20240307/202403072106.jpg

22)Pan, J., Zhang, L., Xu, S., Cheng, X., Yu, H., Bao, J., and Lu, R. Induction of Apoptosis in Human Papillary-Thyroid-Carcinoma BCPAP Cells by Diallyl Trisulfide through Activation of the 

MAPK Signaling Pathway. Journal of Agricultural and Food Chemistry. 2018; 66, 5871-5878.

全文鏈接：/upload/autofile/20240307/202403072734.jpg

發(fā)明專利

一種癌癥聯(lián)合診斷標(biāo)記物及其用途，ZL201710623889.2

團(tuán)隊(duì)合影